A number of hereditary ataxias are caused by inborn errors of metabolism (IEM), most of which are highly heterogeneous in their clinical presentation.Prompt diagnosis is important because disease-specific therapies may be available.In this review, we offer a comprehensive overview of metabolic read more ataxias summarized by disease, highlighting n
Statins are 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors widely used in the treatment of hyperlipidemia.The inhibition of HMG-CoA reductase in the mevalonate pathway leads to the suppression of cell proliferation and induction of apoptosis.The cyclic GMP-AMP synthase (cGAS) stimulator of the interferon genes (STING) signalin
ABSTRACT The gut microbiome is involved in metabolic disorders.Osteopontin (OPN), as a key cytokine, contributes to various inflammation-related diseases.The underlying role of OPN in the microbiome remains poorly understood.Here, we investigated whether OPN could modulate metabolic disorders by affecting gut microbiota.In our present study, we fou
Column leaning in Korean traditional wooden heritage structures has been emphasized in various reports since the first survey report in the 1950s, which established the importance of its measurement.Manual measurements have been carried out for a long time; however, recently, three-dimensional (3D) scanning has been used to obtain accurate data.Thr